At baseline, nodal sites are considered abnormal and measurable when visible and/or palpable, attributable to lymphoma and when they measure >1.5 cm in longest diameter (LDi) or >1.0 cm in shortest diameter (SDi).
Nodes which are both ≤1.5 cm in longest diameter (LDi) and ≤1.0 cm in shortest diameter (SDi) are considered normal and not part of the disease burden.
Since nodal sites may never fully disappear, defining a normalization value is essential to correctly defining response.
- Large nodes (>1.5 cm in longest diameter (LDi)) must decrease in size such that the LDi is ≤1.5 cm to be considered normal.
- Small nodes (LDi >1.0 cm but ≤1.5 cm with a SDi >1.0 cm) must decrease in size such that the SDi ≤ 1.0 cm (the LDi must also remain ≤1.5 cm) to be considered normal.
Extranodal sites are abnormal when either visible on imaging or palpable on physical exam.
Extranodal sites must be absent for Complete Remission.
All sites reported as disease should be attributable to lymphoma.