The analysis of bone marrow is essential to verify a complete remission and alone may be an indicator of progression.
- In order for a patient to be considered a complete responder, bone marrow must be normal by morphology.
- If the sample is considered indeterminate, then it should have a confirmatory normal immunohistochemistry assessment (IHC).
- A missing bone marrow assessment or lack of negative IHC assessment (if bone marrow was indeterminate by morphology) would limit the patient to partial remission at best.
- New positive bone marrow involvement or recurrent bone marrow involvement is considered an indicator of progression.